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World Health Organization : Year 1985-86 ; (Tdr) the Special Programme for Research and Training in Tropical Diseases Chemal Art 86.3: The Development of Artemisinin and its Derivatives ; Report of a Meeting of the Scientific Working Group on the Chemotherapy of Malaria

By Undp, World Bank

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Book Id: WPLBN0000183259
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Reproduction Date: 2005

Title: World Health Organization : Year 1985-86 ; (Tdr) the Special Programme for Research and Training in Tropical Diseases Chemal Art 86.3: The Development of Artemisinin and its Derivatives ; Report of a Meeting of the Scientific Working Group on the Chemotherapy of Malaria  
Author: Undp, World Bank
Volume:
Language: English
Subject: Health., Public health, Wellness programs
Collections: Medical Library Collection, World Health Collection
Historic
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Publisher: World Health Organization

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Bank, Who Special Programme For Research, Training In Tropical Diseases (Tdr, U. W. (n.d.). World Health Organization : Year 1985-86 ; (Tdr) the Special Programme for Research and Training in Tropical Diseases Chemal Art 86.3. Retrieved from http://cn.ebooklibrary.org/


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Medical Reference Publication

Excerpt
Arlemisinin is ~ : I Pa i l t i ~ e a l a r i a l p r i n c i p l e i s o l a t e d from Arcemisia annua -1,. by Cl>inesc s c i e n t l s t f i 111 1972. This novel a n t i m a l a r i a l compound has the s l r u c r u r s of a s c s q u i t e r p e n e l a c t o n c with an i n t e r n a l peroxlde l i n k a g e . Must of the a c t i v e p r i n c i p l e i s founri in t h e l e a v e s and flowering tops Of the plnzlt, thc highest yir?ld being obtained just before flowering. Studlec Ocl , ~ r l c m i e l n J lg~r oduction requirements conducted i n China, I n d i a , Europe and the IJSA i n d i c a t e t h a t y i e l d s vary between 0.01 and 0.17X weight per weight ( w / w ) , dependin}; on plant v a r i e t y , c u l c . i v a t i o u c o n d i t i o n s , and h a r v e s t season and l o c a l i t y . T.yo,~hiLizatlon of the plant before e x t r a c t i o n is t h e most s u i t a l > l c meLllod f o r reseurct, prrriloses, but s i n c e the a r t e m i s i n i n content in l y o p h i l i ~ @ d maLeCit3l i s not s i ; l n i f i c n n t l y thi;iler tllan t h a t obtained from f r e s h or a i r - d r i e d p r e p a r a t i o n s , l y u p h i l i z a r i o n is not p r a c t i c a l or economical f o r t r e a t i n g l a r g e amounts uf R r t e n i s i a .

Table of Contents
CONTENTS SUMMARY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1. INTRODUCTION.. . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2. PRODUCTION OF ARTEMISININ . . . . . . . . . . . . . . . . . . . . . 6 3. METHODS FOR THE QUANTITATLON OF AKTEMISININ AND ITS DERIVATIVES . . 8 3.1 High-Performance Liquid Chromatography (HPLC) . . . . . . . . . 8 3.2 Gas Chromatography-Mass Spectroscopy (EC-MS) . . . . . . . . . 9 3.3 RadIoimmunoassay . . . . . . . . . . . . . . . . . . . . . . . 9 3.4 Conclusions..................,...,.. . 9 I 4. PHAKMACOKINETIC AND METABOLIC STUDIES . . . . . . . . . . . . . . . 10 4.1 Studies in Rabbits . . . . . . . . . . . . . . . . . . . . . . 10 4.2 Studies in Beagle Dogs . . . . . . . . . . . . . . . . . . . . 10 44..34 MSettuadbioelsi cC onSdtuucdtieeds -iLnn -VCihti rnoa .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. 1100 5. CHEMISTRY OF ARTEMISINTN AND OTHER 1,2,4-TRIOXANES . . . . . . . . . 11 5.1 Synthesis of Artemisinin . . . . . . . . . . . . . . . . . . . 11 5.2 Structure/Activity Relationships of Artemisinin Derivatives . . 11 5.3 Synthesis of Trioxanes with Potential Antimalarial Activity . . 12 I 6. ANTIMALARIAL ACTIVITY OF ARTEMISININ AND ITS DERIVATIVES . . . . . . 12 6.1 -In -Vit ro Activity . . . . . . . . . . . . . . . . . . . . . . . 12 6.2 -In -Viv o Activity in Laboratory Models . . . . . . . . . . . . . 14 7. DRUG INTERACTION STUDIES . . . . . . . . . . . . . . . . . . . . . . 15 8. MODE OF ACTION STUDIES . . . . . . . . . . . . . . . . . . . . . . . 16


 
 



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