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Toxicological Review of 2-Methylnaphthalene

By Environmental Protection Agency

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Book Id: WPLBN0000020699
Format Type: PDF eBook
File Size: 0.3 MB
Reproduction Date: 2007
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Title: Toxicological Review of 2-Methylnaphthalene  
Author: Environmental Protection Agency
Volume:
Language: English
Subject: Ecology, Natural resource issues, Environemtal protection
Collections: Environmental Awareness Library Collection
Historic
Publication Date:
Publisher: United States Environmental Protection Agency

Citation

APA MLA Chicago

Agency, E. P. (n.d.). Toxicological Review of 2-Methylnaphthalene. Retrieved from http://cn.ebooklibrary.org/


Description
Excerpt: This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. Note: This document may undergo revisions in the future. The most up-to-date version will be made available electronically via the IRIS Home Page at http://www.epa.gov/iris.

Table of Contents
CONTENTS — TOXICOLOGICAL REVIEW OF 2-METHYLNAPHTHALENE (CAS No. 91-57-6) LIST OF TABLES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v LIST OF FIGURES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v FOREWORD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vi AUTHORS, CONTRIBUTORS, AND REVIEWERS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii 1. INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. CHEMICAL AND PHYSICAL INFORMATION RELEVANT TO ASSESSMENTS . . . . . . . 3 3. TOXICOKINETICS RELEVANT TO ASSESSMENTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 3.1. ABSORPTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 3.2. DISTRIBUTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 3.3. METABOLISM . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 3.4. ELIMINATION AND EXCRETION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 3.5. PHYSIOLOGICALLY-BASED TOXICOKINETIC (PBTK) MODELING . . . . . . 15 4. HAZARD IDENTIFICATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 4.1. STUDIES IN HUMANS—EPIDEMIOLOGY AND CASE REPORTS . . . . . . . . . . 16 4.2. PRECHRONIC AND CHRONIC STUDIES AND CANCER BIOASSAYS IN ANIMALS—ORAL AND INHALATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 4.2.1. Oral Exposure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 4.2.1.1. Prechronic Toxicity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 4.2.1.2. Chronic Toxicity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 4.2.2. Inhalation Exposure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 4.3. REPRODUCTIVE/DEVELOPMENTAL STUDIES—ORAL AND INHALATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 4.4. OTHER STUDIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 4.4.1. Acute Toxicity Data . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 4.4.2. Studies with Methylnaphthalene Mixtures . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 4.4.3. Other Cancer Studies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28 4.4.4. Genotoxicity Studies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 4.5. SYNTHESIS AND EVALUATION OF MAJOR NONCANCER EFFECTS AND MODE OF ACTION—ORAL AND INHALATION . . . . . . . . . . . . . . . . . . . . . . 30 4.5.1. Oral Exposure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 4.5.2. Inhalation Exposure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42 4.5.3. Dermal Exposure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42

 
 



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